Annals of International Medical and Dental Research
Annals of International Medical and Dental Research (AIMDR) is indexed in Index Medicus (IMSEAR), Global Index Medicus, Index Copernicus and Google Scholar
Annals of International Medical and Dental Research
Annals of International Medical and Dental Research (AIMDR) is indexed in Index Medicus (IMSEAR), Global Index Medicus, Index Copernicus and Google Scholar
Shubham Sharma1*, Amit Gupta2, Jason Nongmaithem3, Kajal Awana4, Shayan Ghosh5, Piyush Dua6
Annals of International Medical and Dental Research (AIMDR)| Vol-10, Issue-6 | November-December 2024 | Page: 1-7 | https://doi.org/10.53339/aimdr.2024.10.6.1
Comparison of Analgesic Efficacy of Piroxicam and Ketorolac in Impacted Mandibular Third Molar Surgery: A Prospective Randomized, Double Blind Clinical Study
Shubham Sharma1*, Amit Gupta2, Jason Nongmaithem3, Kajal Awana4, Shayan Ghosh5, Piyush Dua6
Abstract
Background: Postoperative pain following third molar extraction is said to be one of the most acute postsurgical painful conditions with patients require some form of analgesic to deal with it. This study examined the clinical efficacy of piroxicam and ketorolac in managing pain and swelling after lower third molar extraction. Material & Methods: This randomized controlled study was conducted among 24 patients requiring trans-alveolar mandibular molars extraction. GROUP A (12 patients) who were given a single dose of 20 mg piroxicam orally. GROUP B (12 patients) who were given 10 mg ketorolac QID orally. Pain and swelling was evaluated on 1st, 3rd, 7th, and 14th post-operative day. Results: The two study groups were comparable by age and gender. The mean (SD) pain score was lower in Group A (Piroxicam) as compared to Group B (Ketorolac) on Day 1 and 3 and it was found to be statistically significant (p<0.001). There was no significant difference in the mean (SD) pain score between the two groups by Day 7 and 14 of follow up. There was statistically significant reduction in swelling in Group A patients on Day 1, 3 and 7 as compared to Group B patients (p<0.001) but by Day 14 no statistically significant difference in swelling reduction was detected across the two groups. Conclusions: Both piroxicam and ketorolac were effective in reducing postoperative pain and swelling following removal of mandibular third molars with piroxicam showing better control in early postoperative days.
Impacted third molar, Ketorolac, Piroxicam, Pain, Swelling.
Krupa Torne1*
Annals of International Medical and Dental Research (AIMDR)| Vol-10, Issue-6 | November-December 2024 | Page: 8-11 | https://doi.org/10.53339/aimdr.2024.10.6.2
From Viral Illness to Autoimmune Crisis: Atypical Presentation of MOG-Positive ADEM in a Young Child following a Meta-pneumovirus Infection
Krupa Torne1*
Abstract
We report a case of a 3-year-old female who developed MOG-positive Acute Disseminated Encephalomyelitis (ADEM) following a Meta-pneumovirus infection. The patient presented with severe neurological symptoms, including acute encephalopathy, abducent nerve palsy, and rapid deterioration requiring intubation. Serum and cerebrospinal fluid (CSF) MOG antibodies were positive, and MRI revealed multifocal lesions in the brain and spinal cord. Treatment with high-dose steroids, intravenous immunoglobulin (IVIG), and plasmapheresis led to significant clinical improvement. This case underscores the diagnostic complexity of MOG-positive ADEM, particularly when associated with less commonly recognized viral infections like Meta-pneumovirus. The overlap of symptoms with viral encephalopathy emphasizes the need for a comprehensive diagnostic approach, including early MRI and MOG antibody testing, to differentiate from other CNS conditions. The involvement of Meta-pneumovirus, while not commonly reported as a trigger for ADEM, expands the spectrum of viral triggers and highlights the importance of considering a broad range of infectious agents in similar presentations. Early recognition and aggressive treatment were crucial for this patient’s recovery, illustrating the necessity of prompt intervention in MOG-positive ADEM, especially when extensive CNS involvement is observed.
Acute Disseminated Encephalomyelitis (ADEM), Myelin Oligodendrocyte Glycoprotein (MOG) Antibodies, Autoimmune demyelination, Meta-Pneumovirus Infections, Autoimmune Encephalitis.
Clinical and Surgical Management for Cerebral Astrocytoma
Omar Al Awar1*, Layal Abou Zeki2, Marwan Haddad3, Zeinab Nahle4, Patricia Nehme5, Caroline Samaha Jabbour6
Annals of International Medical and Dental Research (AIMDR)| Vol-10, Issue-6 | November-December 2024 | Page: 12-19 | https://doi.org/10.53339/aimdr.2024.10.6.3
Clinical and Surgical Management for Cerebral Astrocytoma
Omar Al Awar1*, Layal Abou Zeki2, Marwan Haddad3, Zeinab Nahle4, Patricia Nehme5, Caroline Samaha Jabbour6
Abstract
Cerebral astrocytoma is a primary brain tumor originating from astrocytes, the star- shaped glial cells that support and protect neurons. It represents a diverse group of tumors with varying degrees of malignancy, classified according to the World Health Organization (WHO) grading system into grades I through IV. Grade I astrocytomas, such as pilocytic astrocytomas, are generally well-circumscribed and less aggressive, while higher-grade tumors like anaplastic astrocytomas (Grade III) and glioblastoma multiforme (Grade IV) exhibit more aggressive behavior and poorer prognoses. Clinical presentation varies with tumor location and grade but commonly includes headaches, seizures, and focal neurological deficits. Diagnostic evaluation typically involves imaging techniques such as MRI and may be supplemented by biopsy for histological confirmation. Treatment strategies are tailored to the tumor grade and include surgical resection, radiation therapy, and chemotherapy. Despite advances in therapeutic approaches, the prognosis remains variable, with higher-grade tumors generally associated with reduced survival rates. Ongoing research focuses on improving early detection, understanding molecular mechanisms, and developing targeted therapies to enhance patient outcomes.
Cerebral astrocytoma, medical treatment, surgical intervention
