Annals of International Medical and Dental Research
Annals of International Medical and Dental Research (AIMDR) is indexed in Index Medicus (IMSEAR), Global Index Medicus, Index Copernicus and Google Scholar
Annals of International Medical and Dental Research
Annals of International Medical and Dental Research (AIMDR) is indexed in Index Medicus (IMSEAR), Global Index Medicus, Index Copernicus and Google Scholar
Study of Patients with Phyllodes Tumor
Kapil Rampal1, Harkanwalpreet Kaur2, Parampreet Singh Sandhu3, Nitesh Snehi4, Ankush Kumar5, Meghna Sharma6*, Sudhir Khichy7
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 1-5 | DOI – 10.53339/aimdr.2023.9.5.1
Study of Patients with Phyllodes Tumor
Kapil Rampal1, Harkanwalpreet Kaur2, Parampreet Singh Sandhu3, Nitesh Snehi4, Ankush Kumar5, Meghna Sharma6*, Sudhir Khichy7
Abstract
Background: Phyllodes tumours (PT) are uncommon fibroepithelial lesions contributing to less than 1% of all breast tumours. Material & Methods: Thirty six patients were included in this retrospective observational study. Data were collected from our Surgical unit, with ethical compliance, in a tertiary care institute of North India over a period of 6 years (Jan 2016- Jan 2022). Results: The mean age of patients with Phyllodes tumour was 30±12 years. 77.8% patients were in pre-menopausal group and 58.3% patients were married. Mean age at first child birth was 23 years. 61.1% patient had disease in the right breast. 11.1% patients had tumour size less than 05 cm, 50% patients had tumour size between 05 to 10 cm while 38.9% patients had size more than 10 cm. 13.9% patients underwent lumpectomy, 30.6% patients had mastectomy and 55.6% cases had wide local excision. 83.3% cases had benign pathology and a recurrence rate of 11.1%. The recurrence in lumpectomy group was observed to be 40% while recurrence in wide local excision (WLE) group was 15%. No recurrence was observed in the mastectomy group. Conclusion: The phyllodes tumour is a rare cause of breast lump. The key to successful management is early diagnosis. Core biopsy should be preferred over FNAC for diagnosis. Treatment options include wide local excision and mastectomy.
Phyllodes tumour, Cystosarcoma Phyllodes, Wide Local Excision, FNAC, Core Tissue Biopsy
Harsitha Bodla1, Manisha Sahu2*, Gitanjali Sahoo3, Kasturi Sai Tharunya4, Priyanka Rama Katiki5
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 6-13 | DOI – 10.53339/aimdr.2023.9.5.2
Placenta Accreta Spectrum-An Obstetrician Nightmare- Its Management and Outcome in a Tertiary Care Centre
Harsitha Bodla1, Manisha Sahu2*, Gitanjali Sahoo3, Kasturi Sai Tharunya4, Priyanka Rama Katiki5
Abstract
Background: Placenta accreta spectrum (PAS) is a rare embryological disorder where abnormal trophoblastic invasion of a part or whole of the placenta occurred into the myometrium of uterine wall. The risk of morbid adherence of placenta increases with each caesarean section. We present our experience of 16 PAS cases management and its outcome in a tertiary care centre. Material & Methods: Retrospective data analysis of PAS patients were done over a period of 2years from September 2019 to August 2021 at department of obstetrics and gynaecology, a tertiary care centre, Bhubaneswar India. Detail obstetric history, their presentation, prenatal investigations, intra operative findings, amount of blood loss, transfusion details of blood and blood product, ICU admission and complications were recorded and analysed. Results: Incidence of PAS in our institute was 0 .59%, all were multigravida, elderly age having previous scared uterus with placenta previa. 9 cases being suspected having adherent placenta prenatally & 11 cases had central placenta previa. All 16 cases(100%) needed caesarean hysterectomy during surgery due to torrential bleeding All cases needed massive blood & blood product transfusion, 12/16 cases required ICU admission. Mortality rate was 12.5 % (2cases) in our study where both were admitted in emergency hour with massive blood loss and diagnosed to have morbidly adherent placenta intraoperatively. Conclusion: Prenatal diagnosis of abnormal invasion of placenta by 2D USG in case of high-risk suspected cases like anterior placenta previa in previous LSCS, reducing caesarean rate by strict to indicated caesarean section and liberal decision for caesarean hysterectomy may help in reducing maternal morbidity and mortality.
Morbidly Adherent, mortality, placenta previa, embryological, Cesarean Hysterectomy
Hemant Kumar Ramsharan Gupta1*
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 14-21 | DOI – 10.53339/aimdr.2023.9.5.3
A Randomized, Double-Blind, Placebo-Controlled, Single-Center Clinical Study to Assess the Efficacy and Safety of the “Folloemi: Hair Growth Serum” in Promoting Hair Growth, Reducing Hair Loss, Improving Hair Thickness, and Preventing Premature Greying of Hair
Hemant Kumar Ramsharan Gupta1*
Abstract
Background: Hair growth serums target and combat hair concerns like androgenetic alopecia, hair loss, thinning hair, and premature greying. These issues can arise from factors like genetics, hormonal imbalances, stress, poor nutrition, and environmental influences. Nutrient deficiencies, specifically biotin, iron, and zinc, can contribute to hair loss and thinning. Hair thinning is also linked to aging, hormonal changes, and inadequate nutrition. The objective of the study is to evaluate the efficacy and safety of hair growth serum in promoting hair growth, reducing hair loss, improving hair thickness, and preventing premature greying of hair. Material & Methods: The Clinical study conducted to assess efficacy and safety of investigational product. Trichoscopic analysis measured hair count/density and premature greying from baseline to 6 months, while hair thickness was assessed via trichoscopy. Hair loss reduction was measured using a comb test. Results: The Test Product demonstrated significant improvements, including a 35.80% increase in hair density, a remarkable reduction in greying hair (40.31% vs. 1.02% for Placebo), a substantial 79.92% improvement in hair thickness, and an impressive 82.30% reduction in hair loss. Notably, the product was found to be safe, with no reported adverse or serious adverse events. Conclusion: The test product proved to be highly effective in promoting hair density and addressing common hair concerns as hair density, greying hair, and hair loss count. These results demonstrated the efficacy of the test product as an advanced solution for improving overall hair health and managing hair-related issues.
Hair Loss, Hair Count, Premature Greying Hair, Hair Thickness, Serum and Scalp
Hemant Kumar Ramsharan Gupta1*
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 22-28 | DOI – 10.53339/aimdr.2023.9.5.4
A Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of the “Noemi: Under Eye Cream” in Reducing the Appearance of Dark Circles, Puffiness, Fine Lines, Crow’s Feet, Pigmentation, and Senescence
Hemant Kumar Ramsharan Gupta1*
Abstract
Background: Under eye concerns like dark circles, puffiness, fine lines, crow’s feet and hyperpigmentation arise from factors such as genetics, aging, lack of sleep, dehydration, and environmental pollutants. Various treatments are available, including creams, serums, and surgeries, but their effectiveness and risks differ. Continued research is necessary to identify safe and effective solutions for these concerns. The objective of the study is to assess the efficacy and safety of ‘Noemi: Under Eye Cream’ in reducing the appearance of dark circles, puffiness, fine lines, crow’s feet, pigmentation, and senescence. Material & Methods: Digital image analysis was used to measure dark circles, puffiness, fine lines, crow’s feet, and pigmentation. The 6-point Fitzpatrick scale assessed darkness in the periorbital area. Improvement in overall skin senescence assessed by the Modified Fitzpatrick Wrinkle and Elastosis Scale. Safety assessment included monitoring of AEs and SAEs. Results: Significant reductions in dark circles, puffiness, fine lines, crow’s feet, and pigmentation were observed in the test group compared to the control group. Results showed superior efficacy of the test product over the placebo including dark circles (96% Test vs. 20% Placebo), puffiness (88% Test vs. 16% Placebo), fine lines (92% Test vs. 28% Placebo), crow’s feet (84% Test vs. 24% Placebo), and pigmentation (96% Test vs. 16% Placebo). No AE/SAEs were reported during the study. Conclusion: Study concluded that the Test product (Noemi under eye dark circle cream) showed better efficacy results with no linked AEs as compared to placebo group.
Dark Circles, Puffiness, Pigmentation and Fine lines.
Hemant Kumar Ramsharan Gupta1*
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 29-36 | DOI – 10.53339/aimdr.2023.9.5.5
A Randomized, Double-Blind, Single Centre, Placebo-Controlled Clinical Study to Assess the Efficacy and Safety of Advanced Senolytic Skin Rejuvenation Cream in Reducing Skin Aging, Dry Skin, Melasma, Wrinkles, Crow’s Feet and Fine Lines
Hemant Kumar Ramsharan Gupta1*
Abstract
Background: Skin aging is a natural process influenced by both internal and external factors. Intrinsic factors like genetics and hormonal changes, along with extrinsic factors such as environmental stressors, contribute to changes in skin appearance and function. With aging, collagen and elastin production declines, leading to wrinkles, fine lines, and sagging skin. The skin becomes drier, thinner, and vulnerable to external damage. The objective of this study is to evaluate the efficacy and safety of “Advanced Senolytic Skin Rejuvenation Cream” in reducing Skin Aging, Dry Skin, Melasma, Wrinkles, Crow’s Feet, Fine Lines. Material & Methods: The study was conducted to assess the efficacy of the investigational product in reducing Anti-aging signs, Dryness, Melasma, Wrinkles, Crow’s Feet and Fine Lines. Digital images captured by a DSLR camera were utilized for evaluation. The assessment involved the use of the Fitzpatrick Wrinkle and Elastosis Scale and the MelasQoL Questionnaire. Safety was measured through AEs/SAEs reported during the study. Results: It was observed that the test product shows better primary and secondary efficacy result with respect to the placebo group. There were 68.34% reduction in aging signs, 69.27% improvement in melasma and 54.11% reduction in wrinkles, crow’s feet and fine lines recorded for the test product. No SAE was reported during the study conduct. Conclusion: Test product indicated better efficacy results with no linked AEs compared to the placebo group. The advanced skin rejuvenation cream showed a significant improvement in aging signs compared to the placebo cream at week 4 (p<0.05) and week 12 (p<0.001).
Anti-aging, wrinkles, fine lines, melasma and skin.
Hemant Kumar Ramsharan Gupta1*
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 37-44 | DOI – 10.53339/aimdr.2023.9.5.6
An Open Label, Single-Arm, Single Center Clinical Study to Assess Efficacy and Safety of the “Skin Rejuvenating SPF 30 Moisturizer” on Improving Skin Hydration, Barrier Function, UV Protection, Antioxidant Activity, and Reducing Skin Pigmentation in Adult Subjects
Hemant Kumar Ramsharan Gupta1*
Abstract
Background: Moisturizers are skincare products that combine water-binding ingredients and emollients to hydrate and protect the skin. They are beneficial for various skin concerns such as dryness, roughness, aging signs, UV damage, melasma, sunspots, freckles, fine lines, and wrinkles. The objective of the study is to evaluate the effectiveness of moisturizer on improving skin hydration, barrier function, UV protection, antioxidant activity and reducing skin pigmentation in adult subjects. Material & Methods: The study assessed skin pigmentation using the 6-point Fitzpatrick scale at baseline, visit-03, visit-04 and visit-05. Skin hydration was measured with a corneometer at the same time points to assess the moisturizer efficacy. Transepidermal water loss was measured using a TEWA meter to evaluate the moisturizer’s impact on improving skin barrier function. Antioxidant activity and UV protection were evaluated with a UV camera. Subject satisfaction was measured over 5-point Likert scale. Results: The study demonstrated that the moisturizer effectively improved skin tone and reduced tanning that resulted in clearer and fairer skin. Skin hydration significantly improved by 90.24% from baseline. TEWL showed an average reduction of 68.28% after 60 days of treatment, indicating improved skin barrier function. The moisturizer provided UV protection and increased antioxidant activity. Subject satisfaction was high, with 94% of participants reporting satisfaction. No SAE was reported. Conclusion: The Noemi Skin Rejuvenating SPF 30 Moisturizer effectively treated dry, rough, aging and UV damaged skin, melasma, sunspots, freckles, fine lines and wrinkles without any associated AEs. These findings highlighted the clinical significance and potential of the moisturizer.
Skin hydration, moisturization, dry skin and UV protection.
Md. Zakirul Islam1*, Md. Abdullahel Kafee2, Anjuman Ara3, Yesmin Akhter4, Jahanara Laizu5, Mohammad Fazlul Huq6, Tahera Khatun7
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 45-52 | DOI – 10.53339/aimdr.2023.9.5.7
Atypical presentation of Dengue outbreak in 2022-study at a dedicated Dengue Hospital in Dhaka, Bangladesh
Md. Zakirul Islam1*, Md. Abdullahel Kafee2, Anjuman Ara3, Yesmin Akhter4, Jahanara Laizu5, Mohammad Fazlul Huq6, Tahera Khatun7
Abstract
Background: Dengue fever, a mosquito-borne viral disease, has emerged as a significant public health concern worldwide. The disease’s presentation can vary widely, with atypical manifestations becoming increasingly common. This study aimed to analyze the atypical presentation of dengue during the 2022 outbreak in a dedicated dengue hospital in Dhaka, Bangladesh. Material & Methods: This retrospective observational study was conducted at the Kurmitola General Hospital, at Dhaka, Bangladesh using data of 300 patients from hospital records collected over a one-year period from January 2022 to December 2022. The variables analyzed included demographic characteristics, clinical presentations, laboratory findings, and hospital stay duration. Results: The majority of the participants were males (74.67%), with the largest proportion falling within the 19-29 age range (39%). The most common clinical presentation was fever (99%), followed by bodyache (44.33%) and gastroenteritis (38%). The majority of participants tested positive for the NS1 antigen (90.33%). The majority had a hospital stay duration between 1 and 3 days (48.67%). Conclusion: The study provides valuable insights into the atypical presentation of dengue, emphasizing the importance of demographic factors, clinical presentations, and laboratory findings in understanding the disease’s manifestation and progression. The findings underscore the importance of early diagnosis and prompt treatment in managing dengue outbreaks. Future research should focus on understanding the factors contributing to atypical presentations and their implications for disease management and control.
Dengue, Fever, Epidemic, Outbreak, Atypical presentation.
Bushra Abrar1*
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 53-60 | DOI – 10.53339/aimdr.2023.9.5.8
Risk Factors for Cardiovascular Disease Among Women with Subclinical Hypothyroidism in a Tertiary Care Hospital – A Retrospective Study
Bushra Abrar1*
Abstract
Background Subclinical hypothyroidism, defined as an elevated serum thyroid-stimulating hormones (TSH) level with normal levels of free thyroxine (FT4) affects up to 10% of the adult population. Subclinical hypothyroidism describes a situation in which thyroid function is only mildly low so that the blood level of thyroxine remains within the normal range but the blood level of TSH is elevated. Subclinical hypothyroidism is a common disorder that increases with age and affects up to 18% of the elderly, with a higher prevalence in women compared to men. The aim of this study was to determine associated risk factors for cardiovascular disease in untreated patients with subclinical hypothyroidism. Material & Methods: This was a retrospective study conducted in the Department of Biochemistry in cooperation with the Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period from January,2013 to December,2013. In our study, we included 50 diagnosed subclinical hypothyroid individuals as cases and 50 euthyroid individuals as control. Results: The mean age was 45.69 ± 8.63 years. The mean of TSH was 9.84 ±6.14 mIU/L, TC & TG was 185.24± 48.15 & 272.43± 90.32 mg/dl respectively. The mean of HDL-C & LDL-C was found 41.83 ±12.56 & 136.4±42.7 mg/dl respectively in our patients. There was a significant increase in all variables of thyroid profile and lipid profile among SCH females except HDL, which was significantly decreased in SCH cases. The percent of patients having borderline elevated cholesterol (200-240 mg/dL), API (>0.21), AI (>3.46) & LCI (>28.10), hypercholesterolemia (>240 mg/dL) and hyperhomocysteinemia (>10.98 µmol/L) were detected in higher percentages in patients than controls. Conclusion: Women with subclinical hypothyroidism have significantly different lipid profiles from women with normal thyroid function. Females with subclinical hypothyroidism were more likely to suffer from cardiovascular disease than euthyroid women. Females with SCH experience a dyslipidemic condition, which is necessary for cardiovascular disease.
Subclinical hypothyroidism, Cardiovascular disease, Risk factors
Johora Akter1*, M Monir Hossain2, Abdullah Al Mamun3
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 61-67 | DOI – 10.53339/aimdr.2023.9.5.9
Complications & Outcome of Ventilated young infants upto 2 Months Age: Experience of a Tertiary Care Paediatric ICU
Johora Akter1*, M Monir Hossain2, Abdullah Al Mamun3
Abstract
Background: Mechanical ventilation, a lifesaving intervention in critical care unit is under continuous evolution in modern era. The management of children with invasive ventilation in developing countries with limited resources is challenging. The aim of the study is to find out complications & outcome of critically ill ventilated young infants up to 2 months age treated in Intensive Care Unit in a tertiary care hospital in Bangladesh. Material & Methods: This observational study was conducted in the Department of Intensive Care Unit of Bangladesh Shishu Hospital & Institute, Sher-e-Bangla Nagar, Dhaka; from January 2020 to December 2020. About 50 young infants up to 2 months age who required ventilation on various indications according to ICU protocol were the subject of this study. All infants were monitored for complications which was identified by daily clinical & radiological examination. Patient was followed up till death or extubation. Moreover, they were extubated when clinically stable both haemodynamically & neurologically. Results: Out of 50 critically ill patients, mortality rate was 74%. Mean age was 14±10.1 days, 84% patients were >34 weeks of gestational age and weight >2500 gm was 52%. Twenty (40%) patients developed complication during ventilation & these were ET tube blocked 35%, re-intubation 20%and VAP 15%, pneumothorax 15%, accidental extubation 15% respectively. Regarding outcome, in 34% patients, the duration of ventilation was more than 5 days, 62% patients stayed in ICU more than 7 days. However, almost three fourth (74%) patients were dead and only 26% were survived during the study period. Conclusion: The prevalence of mortality in the ICU was high. Prolong ventilation (>5days) was important risk factor. Ventilator related complications developed in 40% patients.
Mechanical ventilation, Intensive Care Unit, Young infants, Complications.
Maminur Rahman1*, MD. Jahirul Islam2, Khadijatul Kubra3, Noor-E-Jannat Tania4
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 68-75 | DOI – 10.53339/aimdr.2023.9.5.10
A Comparative Study of Intramuscular Pethidine and Intravenous Ketorolac as Analgesic for Postoperative Pain Management in Major Abdominal Surgery in Paediatric Patients
Maminur Rahman1*, MD. Jahirul Islam2, Khadijatul Kubra3, Noor-E-Jannat Tania4
Abstract
Background: Postoperative pain after surgery causes uneasiness for the patients, however can bring delayed hospitalization, expanded morbidity and respiratory issues and readmission. For postoperative pain control, various techniques and prescriptions have been proposed, like non-steroidal anti-inflammatory drugs (NSAIDs) and narcotics. Ketorolac, an NSAIDs and pethidine, a narcotic analgesic, are widely used for pain management. In this study, the effects of these two medications on children aged 1 to 15 who had abdominal surgery were investigated and compared. The aim of the study is to assess and compare the effect of intramuscular pethidine and intravenous ketorolac as analgesic for postoperative pain management in major abdominal surgery in paediatric patients. Material & Methods: This retrospective cohort research was conducted in the Department of Paediatric Anaesthesiology and Surgical ICU, Bangladesh Shishu Hospital and Institute, Dhaka, Bangladesh, from July 2020 to June 2023.The Institutional Ethics Committee approved this study and informed parental written consent was obtained from the parents before collecting the patients’ information. Results: Between pethidine and ketorolac groups, the mean and standard deviation of postoperative pain one hour after surgery were 3.60 ± 1.21 and 3.79 ± 0.93 respectively. The pethidine pain relief group scale was significantly low (P<0.001). The difference between the two groups’ postoperative pain intensity 2 hours after surgery was significant (P = 0.006), at 3.49 ± 1 and 3.60 ± 1.15 respectively. The variation in postoperative pain intensity in the pethidine group was measurably lower than the ketorolac group (P = 0.019). Conclusion: Both of the analgesics, intramuscular pethidine and intravenous ketorolac, are effective for postoperative pain management in major abdominal surgery in paediatric patients. Intramuscular pethidine is more effective than intravenous ketorolac but to some extent ketorolac found safer than pethidine.
Postoperative pain, abdominal surgery, ketorolac, pethidine, analgesic
A Total Analysis on Radiological and Per Operative Findings in Gynaecological Malignancy
Sumaya Akter1*, Jinnatun Nur2, Joysree Saha3, Shain Fariya4
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 76-84 | DOI – 10.53339/aimdr.2023.9.5.11
A Total Analysis on Radiological and Per Operative Findings in Gynaecological Malignancy
Sumaya Akter1*, Jinnatun Nur2, Joysree Saha3, Shain Fariya4
Abstract
Background: Identification and staging of gynaecological cancer can be performed by radiology. Earlier identification and staging can save a patient’s life which requires conformity. In this study, radiological findings and surgicopathologic diagnosis are compared for gynaecological malignancy to find the best way before surgical attempt. The aim of this study was to compare the diagnostic performance and interobserver variability of computed tomography (CT) and magnetic resonance (MR) imaging in the pretreatment evaluation of early invasive cervical cancer. Material & Methods: This retrospective study was conducted in the Department of Obstetrics & Gynaecology in Popular Medical College and Hospital, Dhaka, Bangladesh during the period from March 2018 to March 2023. This study had institutional review board approval and informed consent for evaluation of preoperative CT (n= 40) and/or MR imaging (n= 70) studies in 110 women (median age, 43 years; range, 22–81 years). Our radiologists (experience, 7-15 years) interpreted the CT outputs, and four radiologists (experience, 12-20 years) interpreted the MR studies retrospectively. Tumor visualization and detection of parametrial invasion were evaluated with receiver operating characteristic curves (P≤0.05). Descriptive statistics for staging and k statistics for reader agreement were calculated. Surgical pathologic findings were the reference standard. Results: For CT multirater k value was 0.26 and for MR imaging 0.44 for staging, 0.16 and 0.32 for tumor visualization respectively, and 20.04 and 0.11 for detection of parametrial invasion; for advanced stage cancer (≥IIB), sensitivities were 0.14–0.38 and 0.40–0.57, positive predictive values (PPVs) were 0.38–1.00 and 0.32–0.39, specificities were 0.84–1.00 and 0.77–0.80, and negative predictive values (NPVs) were 0.81–0.84 and 0.83–0.87. MR imaging was found significantly better than CT for tumor visualization (P < .001) and detection of parametrial invasion (P= .047). Conclusion: According to the observers, MR imaging was significantly better than CT for tumor visualization and detection of parametrial invasion. The modalities were similar for staging, sharing low sensitivity and PPV but relatively high NPV and specificity.
Gynaecological cancer, radiological findings, surgicopathologic findings, sonography, MR, CT.
Mohammad Fazlul Huq1*, Md. Abdullahel Kafee2, Md. Abul Khair Yousuf3, Maimuna Sultana4, Md. Al Rizwan Russel5, Tanvir Ahmed6, Md. Lokman Hossain Talukder7, Mohammad Zahirul Islam8
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 85-92 | DOI – 10.53339/aimdr.2023.9.5.12
Comparison of Adverse Effects Following First Dose of Covishield™ in Covid Vaccine Recipients with or without Comorbidities in a Tertiary Care Hospital
Mohammad Fazlul Huq1*, Md. Abdullahel Kafee2, Md. Abul Khair Yousuf3, Maimuna Sultana4, Md. Al Rizwan Russel5, Tanvir Ahmed6, Md. Lokman Hossain Talukder7, Mohammad Zahirul Islam8
Abstract
Background: The COVID-19 vaccines have significantly altered the course of the pandemic. While incredibly beneficial, some recipients may experience mild to moderate side effects post-vaccination, which are typically signs of the body building protection. The aim of the study is to compare the adverse effects following first dose of Covishield™ vaccination in vaccine recipients with or without comorbidities. Material & Methods: This cross-sectional study was conducted in Department of Medicine, Kurmitola General Hospital, Dhaka, Bangladesh, during the period from February 2021 to April 2021. Total 200 study subjects who received first dose of Covid-19 vaccine- “Covishield™” are included in this study. Results: In this study, majority were male (63.5%) with a mean age of 48.7 years (SD±6.2 years). Among the study subjects, 30.5% had comorbidities with HTN (62.3%) and DM (45.9%) being the most common. Among these, fever was a prevalent symptom, experienced by 49.2% of those with comorbidities compared to 33.1% without. Muscle pain was more common among those without comorbidities (25.9% vs 8.2%). Some symptoms like vertigo, weakness, diarrhea, and body ache were exclusive to those with comorbidities. Side effects varied across different comorbidities, with HTN patients reporting fever (21.3%) and DM patients experiencing fever (23%). Conclusion: The study demonstrates that adverse effects after vaccination were more common in individuals with comorbidities, with fever being the most prevalent. However, muscle pain was more common in individuals without comorbidities.
Comparison, Adverse Effects, Covishield™, Covid-19, Vaccine Recipients, and Comorbidities
Laila Sultana1*, Mohammad Sadaqul Islam Sikder2, Gulshan Ara Begum3, Rehana Afroze Ruma4
Annals of International Medical and Dental Research (AIMDR)| Vol-9, Issue-5 | September-October 2023 | Page: 93-102 | DOI – 10.53339/aimdr.2023.9.5.13
Evaluation of HbA1c, serum Magnesium (Mg) and Lipid Profile Among type 2 Diabetic Foot Ulcer and without Foot Ulcer Patients
Laila Sultana1*, Mohammad Sadaqul Islam Sikder2, Gulshan Ara Begum3, Rehana Afroze Ruma4
Abstract
Background: Diabetic foot ulcers are the major macrovascular complication of diabetes resulting in significant morbidity associated with diabetes and a leading cause of hospital admission in developed countries. [6] About 1-4% of people with type 2 diabetes develop foot ulcer every year and it results in gangrene and lower extremity amputation associated with socioeconomic impact. The aim of this study was to evaluate the HbA1c, serum Magnesium (Mg) and lipid profile among type 2 diabetic foot ulcer and without foot ulcer patients. Materials & Methods: This was a cross-sectional study and was conducted in the Department of Biochemistry and Molecular Biology, BIRDEM Academy, Dhaka, Bangladesh during the period from January 2018 to December 2018. In our study, we included 120 patients divided into two groups – Group I (Type 2 diabetic patients with foot ulcer) and Group II (Type 2 diabetic patients without foot ulcer). Results: The mean age of the study subjects was 49 years and most of them were male. The high hemoglobin A1c (HbA1c ≥7.5%) was significantly more affected by diabetic foot ulcer than compared with near normal HbA1c (61.6% vs 31.9%). The percentage of hypomagnesemia was 69.6% and 30.4% respectively. It was also observed that the percentage of hypomagnesemia was significantly higher in the diabetic foot ulcer group. The mean value of TC, TAG, LDL-c were significantly higher in foot ulcer group whereas HDL-c was significantly lower in diabetic foot ulcer group than in the without foot ulcer group. Conclusion: In conclusion, magnesium level should be maintained in DM patients, whether they have or do not have foot ulcer, and magnesium supplementation may be helpful for these individuals.
Diabetes mellitus, Foot ulcer, HbA1c, Serum Magnesium
